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The high uncertainty relies on the high difficulty in understanding the multiple processes and players involved, related to the non-linearity between the change in aerosols and multiple cloud properties. Earth system models are an indispensable tool to predict the future climate. They are process-based models, and they are directly affected by the uncertainty in the understanding of the aerosol-cloud dynamics. The present work investigates the ability of the CMIP6 models to reproduce the relationship between the cloud droplet number concentration (CDNC) and the aerosol optical depth (AOD), taken as a proxy of the number of aerosols (or CCN, cloud condensation nuclei). First a comparison between the modelled and observed AOD (data was not available for CDNC) was conducted to individuate the best performance within the models in reproducing this variable. The observational data were from MODIS data and the comparison was done on the climatological mean over the 2000-2014 period. Using different statistical parameters, a ranking was produced and the model GFDL-ESM4 resulted to better perform over the other models. Afterwards, in order to account for the non-linearity of the process, joint histogram have been used to reproduce the relationship between AOD and CDNC. The objective was to compare the modelled results on a global and local scale with the MODIS data from the study Gryspeerdt et al 2016, in order to see if the model could capture the complex relationship. The different time resolution didn’t allow to proceed to a direct comparison of the plots, but they result to be compatible, leading to the conclusion that GFDL-ESM4 model is able to well reproduce this interaction. The importance of separating the analysis into the liquid water content and the ice content is also appreciated, which is even more evident in regional analysis. Further investigations are needed to better compare and quantify the performance of the CMIP6 models in reproducing the observed aerosol-cloud interaction. https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/ http://schema.org/encodingFormat application/ld+json https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/ http://schema.org/hasPart https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/folders/177f97e6-422c-4fe2-8969-69a173ae9b15 https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/ http://schema.org/hasPart https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/folders/507106ed-b4df-4b91-93d8-cfeaa1181cff https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/ http://schema.org/hasPart https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/folders/87817886-1364-4e5b-a7c7-7689ee71b9ef https://w3id.org/ro-id/dd948b04-bfa4-44b0-814b-19f7daff6b8c/ http://schema.org/hasPart 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"OCTOPUS project - explOring aerosol-Cloud inTeractiOns in CMIP6 models Using joint-histogramS." ROHub. 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