[ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#pubinfo", "@graph": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#sig", "http://purl.org/nanopub/x/hasAlgorithm": [ { "@value": "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey": [ { "@value": "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature": [ { "@value": "Ls/zauvLpbfRhYdRIwdUmPe+S/Sz8Wecb4rRMHeP7+1mnE7/oyM34AF8fy8bNyQBIPfc4T1D8ezK2X30IZSdrRx8EMFv701bE0cBwK0BUUUNG/AQqSkhJ4JW0EpBS+ubbFENYEIi/woCmYMMf9YrbYjUrDRIq8maq6U18o7iFeg=" } ], "http://purl.org/nanopub/x/hasSignatureTarget": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0" } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0", "http://purl.org/dc/terms/created": [ { "@value": "2021-09-13T13:14:11.326+02:00", "@type": "http://www.w3.org/2001/XMLSchema#dateTime" } ], "http://purl.org/dc/terms/creator": [ { "@id": "https://orcid.org/0000-0002-7641-6446" } ], "http://purl.org/nanopub/x/supersedes": [ { "@id": "http://purl.org/np/RAW5kVwsRJ39K39wCgY5vvF6ha59l1ji00G_ZMV03HBps" } ], "http://www.w3.org/ns/prov#generatedAtTime": [ { "@value": "2021-08-24T15:53:47.2920" } ], "http://www.w3.org/ns/prov#wasAttributedTo": [ { "@id": "https://orcid.org/0000-0002-7641-6446" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate": [ { "@id": "http://purl.org/np/RAcm8OurwUk15WOgBM9wySo-T3a5h6as4K8YR5MBrrxUc" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate": [ { "@id": "http://purl.org/np/RA2vCBXZf-icEcVRGhulJXugTGxpsV5yVr9yqCI1bQh4A" }, { "@id": "http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM" }, { "@id": "http://purl.org/np/RAjpBMlw3owYhJUBo3DtsuDlXsNAJ8cnGeWAutDVjuAuI" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate": [ { "@id": "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#assertion", "@graph": [ { "@id": "http://purl.obolibrary.org/obo/MONDO_0024612", "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Disease" } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#association", "http://www.w3.org/1999/02/22-rdf-syntax-ns#object": [ { "@id": "http://purl.obolibrary.org/obo/MONDO_0024612" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate": [ { "@id": "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject": [ { "@id": "https://identifiers.org/DRUGBANK:DB01267" } ], "@type": [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" } ], "https://w3id.org/biolink/vocab/has_population_context": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#cohort" } ], "https://w3id.org/biolink/vocab/provided_by": [ { "@id": "https://w3id.org/um/NeuroDKG" } ], "https://w3id.org/biolink/vocab/publications": [ { "@id": "https://pubmed.ncbi.nlm.nih.gov/31096228" } ], "https://w3id.org/biolink/vocab/relation": [ { "@id": "https://w3id.org/um/neurodkg/OffLabelIndication" } ] }, { "@id": "https://identifiers.org/DRUGBANK:DB01267", "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Drug" } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#cohort", "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Children and adolescents" } ], "https://schema.org/requiredMaxAge": [ { "@value": "17" } ], "https://schema.org/requiredMinAge": [ { "@value": "12" } ], "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Cohort" } ] } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#provenance", "@graph": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#assertion", "http://www.w3.org/ns/prov#generatedAtTime": [ { "@value": "2021-08-24T15:53:47.2920" } ] } ] }, { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#Head", "@graph": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0", "http://www.nanopub.org/nschema#hasAssertion": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo": [ { "@id": "http://purl.org/np/RA9SaVBI5EOMPxLaIBR_I3Zc-iX-Eq_QzdkcGGswpg4m0#pubinfo" } ], "@type": [ "http://www.nanopub.org/nschema#Nanopublication" ] } ] } ]