[ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#provenance", "@graph": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#assertion", "http://www.w3.org/ns/prov#generatedAtTime": [ { "@value": "2021-08-16T20:58:23.743466", "@type": "http://www.w3.org/2001/XMLSchema#dateTime" } ] } ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#Head", "@graph": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ", "http://www.nanopub.org/nschema#hasAssertion": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#pubInfo" } ], "@type": [ "http://www.nanopub.org/nschema#Nanopublication" ] } ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#assertion", "@graph": [ { "@id": "http://purl.obolibrary.org/obo/MONDO_0100081", "@type": [ "https://w3id.org/biolink/vocab/Disease" ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#association", "http://www.w3.org/1999/02/22-rdf-syntax-ns#object": [ { "@id": "http://purl.obolibrary.org/obo/MONDO_0100081" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate": [ { "@id": "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject": [ { "@id": "https://identifiers.org/DRUGBANK:DB00656" } ], "@type": [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2 contains information on trazodone and mirtazapine). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001)." } ], "https://w3id.org/biolink/vocab/has_population_context": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#context" } ], "https://w3id.org/biolink/vocab/provided_by": [ { "@id": "https://w3id.org/um/NeuroDKG" } ], "https://w3id.org/biolink/vocab/publications": [ { "@id": "https://pubmed.ncbi.nlm.nih.gov/31622593" } ], "https://w3id.org/biolink/vocab/relation": [ { "@id": "https://w3id.org/um/neurodkg/OffLabelIndication" } ] }, { "@id": "https://identifiers.org/DRUGBANK:DB00656", "@type": [ "https://w3id.org/biolink/vocab/Drug" ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#context", "@type": [ "https://w3id.org/biolink/vocab/Cohort" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Adults" } ] } ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#pubInfo", "@graph": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ#sig", "http://purl.org/nanopub/x/hasAlgorithm": [ { "@value": "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey": [ { "@value": "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature": [ { "@value": "CCn2S0xmLImmnm3K08222JMFHbNyLhUlKIu3Bs/vMcQ1G91V/rrj+/2VyJZ8IGogeNLKx6f3+8aVE46OArH+FxPNsQFfu+LM+ca9UJ9KeCvZVIpEKjKT2YIWDCHRRRU0LmfGBMCpN76FxakXfEvr+WjFC2a5yjKr1cEnAYbEyaI=" } ], "http://purl.org/nanopub/x/hasSignatureTarget": [ { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ" } ] }, { "@id": "http://purl.org/np/RAOBBG1l1-iImoJMSkSp3lONgFIYEorvfHbq_ZG-5FcIQ", "http://www.w3.org/ns/prov#generatedAtTime": [ { "@value": "2021-08-16T20:58:23.743466", "@type": "http://www.w3.org/2001/XMLSchema#dateTime" } ], "http://www.w3.org/ns/prov#wasAttributedTo": [ { "@id": "https://orcid.org/0000-0002-7641-6446" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate": [ { "@id": "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] } ] } ]