@prefix this: <https://w3id.org/np/RAngbyT2iZe4xYUcPnTnDFKDaiL5-tSmoUYzF9RK3LHdE> .
@prefix sub: <https://w3id.org/np/RAngbyT2iZe4xYUcPnTnDFKDaiL5-tSmoUYzF9RK3LHdE/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix mac: <https://w3id.org/spaces/mac/r/ontology/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  this: dct:license <https://creativecommons.org/licenses/by/4.0/>;
    <https://w3id.org/fdof/ontology#hasEncodingFormat> <https://www.iana.org/assignments/media-types/application/trig>;
    <https://w3id.org/fdof/ontology#materializes> sub:Alpha-RBD-Variant;
    <https://www.w3.org/ns/dcat#accessURL> this: .
  
  sub:Alpha-RBD-Variant a <https://w3id.org/fdof/ontology#FAIRDigitalObject>, mac:SpikeRBDVariant;
    dct:creator orcid:0000-0001-8888-635X;
    dct:isPartOf <https://w3id.org/np/RAXPu-iuezz8swvd6RWIba3VzV0cp94Aq3pTzVst9_nPk/StayAhead-Project>;
    dct:publisher <https://ror.org/027bh9e22>;
    dct:references <https://doi.org/10.3389/fbinf.2025.1634111>;
    dct:source <https://doi.org/10.71728/hw56-vj34>;
    rdfs:comment "SARS-CoV-2 Spike RBD variant Alpha, carrying the N169Y substitution (corresponding to N501Y in the full Spike numbering). Pango lineage B.1.1.7. Designated a Variant of Concern (VOC) by the WHO. RBD anchor FDO for the MAC FAIR Digital Twin observation cluster — all Type 2-8 observation FDOs of this variant link back here via mac:isObservationOf.";
    rdfs:label "Spike RBD Variant Alpha (N169Y)";
    <https://w3id.org/fdof/ontology#hasMetadata> this:;
    mac:hasGISAIDAccession "EPI_ISL_601443";
    mac:hasGISAIDSeqId "N501Y";
    mac:hasMACSeqId "N169Y";
    mac:hasPangoLineage "B.1.1.7";
    mac:hasParentProtein <https://www.uniprot.org/uniprot/P0DTC2>;
    mac:hasRBDSequence "TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGP";
    mac:hasWHOVariantName "Alpha";
    <https://www.w3.org/ns/dcat#contactPoint> "e.a.schultes@lacdr.leidenuniv.nl" .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0001-8888-635X .
}

sub:pubinfo {
  this: dct:created "2026-06-01T10:23:12Z"^^xsd:dateTime;
    dct:creator orcid:0000-0001-8888-635X;
    dct:license <https://creativecommons.org/licenses/by/4.0/>;
    npx:introduces sub:Alpha-RBD-Variant;
    npx:supersedes <https://w3id.org/np/RA4BHII2Bz7HfpUkaSJqNmhjF8F7hyWpCJnvXYkA4EP_M>;
    rdfs:label "Spike RBD Variant Alpha (N169Y)";
    nt:wasCreatedFromProvenanceTemplate <https://w3id.org/np/RA7lSq6MuK_TIC6JMSHvLtee3lpLoZDOqLJCLXevnrPoU>;
    nt:wasCreatedFromPubinfoTemplate <https://w3id.org/np/RA0J4vUn_dekg-U1kK3AOEt02p9mT2WO03uGxLDec1jLw>,
      <https://w3id.org/np/RAMEgudZsQ1bh1fZhfYnkthqH6YSXpghSE_DEN1I-6eAI>, <https://w3id.org/np/RARW4MsFkHuwjycNElvEVtuMjpf4yWDL10-0C5l2MqqRQ>,
      <https://w3id.org/np/RAukAcWHRDlkqxk7H2XNSegc1WnHI569INvNr-xdptDGI>;
    nt:wasCreatedFromTemplate <https://w3id.org/np/RADOnITa1gjGIQtuENvlB2I7hykzrASzake1bIjGLiAtM> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQD3w/IUb755GIzp3ueODYkgELhyq4Clygb5Kspge50xo+n8uC/IvXwi+ukRjEpdfX/JZ09yKUCJ2AMMr/QchrsP1Xhg9Q3fEZ4E12XqFd5jX00Qs0K5XZwjBaV8NdDTJW9I4gpcyh0cry7hSBAWHkXEkqbK+lQvR4UFAKejFq6u/wIDAQAB";
    npx:hasSignature "J3GenG6t5SPEIm/c+e34CBXZSf8EUjDKESzsGeV1FENGpJAuuCBqW6hV/2unMu1ax/DsgvvELK0yeAo9maf9CX9kih49GkwhtDhnu2JThci8Xqy+SqwjjRDcw/hLmmRygLpNG4keNQn9QkjJcPi0UDznD0pyL/7ac0YL4+FDEOI=";
    npx:hasSignatureTarget this:;
    npx:signedBy orcid:0000-0001-8888-635X .
}